■ 所属研究室
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■ 学位
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■ 現在の専門分野
細胞生物学, 分子生物学, 薬系化学、創薬科学, 腫瘍診断、治療学, 進化生物学, 血液、腫瘍内科学, ウイルス学, 医化学 (キーワード:RNA治療学、核酸医薬、遺伝子発現制御、TRUE gene silencing、sgRNA、tRNase Z、多発性骨髄腫、造血器腫瘍、腫瘍微小環境、マクロファージ、SARS-CoV-2、COVID-19、5'-half-tRNA、31/32-nt Y4-RNA断片、バイオマーカー)
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■ 学歴
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■ 職歴
1.
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1987/04~1989/03
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佐渡厚生病院附属佐渡看護学校 非常勤講師
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2.
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1990/04~1993/02
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北海道大学 医学部第一生化学講座 助手
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3.
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1991/04~1993/03
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王子総合病院附属看護学校 非常勤講師
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4.
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1993/03~1996/02
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JT生命科学研究所 研究員
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5.
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1995/04~1996/03
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千葉大学 大学院薬学研究科 非常勤講師
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6.
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1996/08~1999/11
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Brigham Young University Department of Chemistry and Biochemistry 研究員
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7.
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1999/12~2002/03
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農林水産省食品総合研究所 研究員
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8.
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2002/04~2007/03
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新潟薬科大学 応用生命科学部 応用生命科学科 助教授
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9.
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2007/04~2014/09
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新潟薬科大学 応用生命科学部 応用生命科学科 教授
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10.
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2011/04~2012/03
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北海道大学大学院 非常勤講師
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11.
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2014/10~2023/03
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新潟薬科大学 健康・自立総合研究機構 教授
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12.
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2015/04~2017/03
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北海道大学歯学部 非常勤講師
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5件表示
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全件表示(12件)
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■ 所属学会
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■ 著書・論文歴
1.
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著書
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カラー生化学 第4版 (共著) 2015/03
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2.
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著書
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カラー生化学 第3版 (共著) 2003/05
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3.
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論文
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TRUE Gene Silencing International Journal of Molecular Sciences 23,pp.5387 (単著) 2022/05
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4.
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論文
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Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus Biochemical and Biophysical Research Communications 587,pp.63-68 (共著) 2022/01
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5.
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論文
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Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons Biochemical and Biophysical Research Communications 585,pp.162-168 (共著) 2021/12
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6.
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論文
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Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect Journal of Nucleic Acids 2021 (共著) 2021/11
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7.
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論文
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Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems In Vivo 35,pp.3125-3135 (共著) 2021/11
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8.
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論文
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A naked antisense oligonucleotide with phosphorothioate linkages is taken up intracellularly more efficiently but functions less effectively Biochemical and Biophysical Research Communications 573,pp.140-144 (共著) 2021/08
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9.
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論文
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Heptamer-type small guide RNA that can shift macrophages toward the M1 state Blood Cells, Molecules and Diseases 86,pp.102503 (共著) 2021/02
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10.
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論文
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The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression Biochemistry and Biophysics Reports 26,pp.100918 (共著) 2021/02
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11.
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論文
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RNA-hydrolyzing activity of metallo-β-lactamase IMP-1 PLoS ONE 15,pp.e0241557 (共著) 2020/10
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12.
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論文
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Large-Scale Isolation of Three O-Methyl Anthocyanins from Bilberry (Vaccinium myrtillus L.) Extract Chem Pharm Bull (Tokyo) (共著) 2020/09
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13.
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論文
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Mastication Affects Transcriptomes of Mouse Microglia ANTICANCER RESEARCH 40,pp.4719-4727 (共著) 2020/08
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14.
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論文
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The 31-nucleotide Y4-RNA fragment in plasma is a potential novel biomarker Non-coding RNA Research 5 (共著) 2019/12
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15.
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論文
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Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study Emerging Microbes and Infections 8,pp.1688 (共著) 2019/11
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16.
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論文
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Evaluation of double heptamer-type sgRNA as a potential therapeutic agent against multiple myeloma Blood Cells Mol Dis 79,pp.102341 (共著) 2019/11
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17.
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論文
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Potential physiological roles of the 31/32-nucleotide Y4-RNA fragment in human plasma Non-coding RNA Research 4,pp.135 (共著) 2019/11
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18.
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論文
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The Y4-RNA fragment, a potential diagnostic marker, exists in saliva Non-coding RNA Research 2,pp.122-128 (共著) 2017/07
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19.
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論文
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Microbicidal Effects of Stored Aqueous Ozone Solution Generated by Nano-bubble Technology In Vivo 31,pp.579-583 (共著) 2017/06
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20.
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論文
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TRUE Gene Silencing: Screening of a Heptamer-type Small Guide RNA Library for Potential Cancer Therapeutic Agents Journal of Visualized Experiments 112,pp.e53879 (共著) 2016/06
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21.
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論文
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Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing Molecular Medicine Reports 12,pp.6365-6369 (共著) 2015/10
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22.
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論文
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Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines PLoS One 10,pp.e0118631 (共著) 2015/03
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23.
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論文
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Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing PLoS One 9,pp.e114121 (共著) 2014/12
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24.
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論文
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Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies Leukemia Research 38,pp.808-815 (共著) 2014/07
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25.
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論文
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Induction of apoptosis of leukemic cells by TRUE gene silencing using small guide RNAs targeting the WT1 mRNA Leukemia Research 37,pp.580-585 (共著) 2013/05
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26.
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論文
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A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells Cancer Letters 328,pp.362-368 (共著) 2013/01
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27.
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論文
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Elimination of specific miRNAs by naked 14-nt sgRNAs PLoS ONE 7,pp.e38496 (共著) 2012/06
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28.
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論文
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Expanding the utility of heptamer-type sgRNA for TRUE gene silencing Biochem. Biophys. Res. Commun. 416,pp.427-432 (共著) 2011/12
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29.
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論文
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Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit Nucleic Acids Res 39,pp.5264-5275 (共著) 2011/07
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30.
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論文
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Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells The International Journal of Biochemistry and Cell Biology 43,pp.760-767 (共著) 2011/05
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31.
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論文
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tRNase ZとTRUE gene silencing 化学と生物 49,150-152頁 (共著) 2011/03
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32.
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論文
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Human cytosolic tRNase ZL can downregulate gene expression through miRNA FEBS Lett. 583,pp.3241-3246 (共著) 2009/10
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33.
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論文
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Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process Biochem Biophys Res Commun 383,pp.125-129 (共著) 2009/05
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34.
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論文
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Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression 14,pp.141-153 (共著) 2009/02
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35.
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論文
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Inhibition of vascular endothelial growth factor expression by TRUE gene silencing Biochem and Biophys Res Commun 379,pp.924-927 (共著) 2009/02
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36.
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論文
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Modulation of gene expression by human cytosolic tRNase ZL through 5'-half-tRNA PLoS ONE 4,pp.e5908 (共著) 2009/02
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37.
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論文
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Functional analyses for tRNase Z variants: An aspartate and a histidine in the active site are essential for the catalytic activity Biochim Biophys Acta 1784,pp.2079-2085 (共著) 2008/12
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38.
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論文
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Escherichia coli tRNase Z can shut down growth probably by removing amino acids from aminoacyl-tRNAs Genes to Cells 13,1087-1097頁 (共著) 2008/11
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39.
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論文
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The flexible arm of tRNase Z is not essential for pre-tRNA binding but affects cleavage site selection Journal of Molecular Biology 381,289-299頁 (共著) 2008/08
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40.
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論文
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Regulation of the human tRNase ZS gene expression FEBS Lett. 582,pp.2532-2536 (共著) 2008/07
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41.
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論文
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The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes Acta Cryst. F63,pp.637-641 (共著) 2007/08
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42.
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論文
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Gene-silencing by the tRNA maturase tRNase ZL under the direction of small guide RNA Gene Therapy 14,pp.78-85 (共著) 2007/01
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43.
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論文
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Isolation of a Gram-positive poly(3-hydroxybutyrate) (PHB)-degrading bacterium from compost, and cloning and characterization of a gene encoding PHB depolymerase of Bacillus megaterium N-18-25-9 FEMS Microbiol Lett 264,pp.152-159 (共著) 2006/11
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44.
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論文
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Identification by Mn2+ rescue of two residues essential for the proton transfer of tRNase Z catalysis Nucleic Acids Research 34,pp.3811-3818 (共著) 2006/08
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45.
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論文
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Site-directed mutagenesis of the serotonin 5-Hydroxytryptamine2c receptor: identification of amino acids responsible for sarpogrelate binding Biol Pharm Bull 29,pp.1645-1650 (共著) 2006/08
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46.
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論文
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Substrate recognition ability differs among various prokaryotic tRNase Zs Biochem. Biophys. Res. Commun. 345,pp.385-393 (共著) 2006/06
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47.
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論文
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Unstructured RNA is a substrate for tRNase Z Biochemistry 45,pp.5486-5492 (共著) 2006/05
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48.
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論文
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Microbial communities in the garbage composting with rice hull as an amendment revealed by culture-dependent and -independent approaches J Biosci Bioeng 101,pp.42-50 (共著) 2006/01
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49.
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論文
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The T-loop structure is dispensable for substrate recognition by tRNase ZL Journal of Biological Chemistry 280,pp.22326-22334 (共著) 2005/06
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50.
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論文
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The Missense Mutations in the Candidate Prostate Cancer Gene ELAC2 Do Not Alter Enzymatic Properties of its Product Cancer Letters 222,pp.211-215 (共著) 2005/05
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51.
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論文
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Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima Journal of Biological Chemistry 280,pp.14138-14144 (共著) 2005/04
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52.
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論文
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DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912. Microbiology 151,pp.281-290 (共著) 2005/01
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53.
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論文
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Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL Nucleic Acids Research 33,pp.235-243 (共著) 2005/01
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54.
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論文
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The N-terminal half domain of the long form of tRNase Z is required for the RNase 65 activity Nucleic Acids Research 32,pp.4429-4438 (共著) 2004/08
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55.
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論文
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A novel 4-base-recognizing RNA cutter that can remove the single 3' terminal nucleotides from RNA molecules. Nucleic Acids Research 32,pp.4429-4438 (共著) 2004/05
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56.
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論文
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A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima Journal of Biological Chemistry 279,pp.15688-15697 (共著) 2004/01
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57.
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論文
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Intracellular mRNA cleavage by 3' tRNase under the direction of 2'-O-methyl RNA heptamers Nucleic Acids Research 31,pp.4354-4360 (共著) 2003/07
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58.
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論文
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A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. Nucleic Acids Research 31,pp.2272-2278 (共著) 2003/03
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59.
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論文
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The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs. Journal of Molecular Biology 312,pp.975-985 (共著) 2001/10
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60.
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論文
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The RNA/protein symmetry hypothesis: Experimental support for reverse translation of primitive proteins Journal of Theoretical Biology 209,pp.181-187 (単著) 2001/03
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61.
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論文
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小さなRNAでヒト遺伝子の発現を抑制する新手法発見 遺伝 55,20-21頁 (単著) 2001
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62.
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論文
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Correct folding of a ribozyme induced by non-specific macromolecules. European Journal of Biochemistry 267,pp.2738-2745 (単著) 2000/05
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63.
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論文
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Anomalous RNA substrates for mammalian tRNA 3' processing endoribonuclease FEBS Letters 472,pp.179-186 (単著) 2000/04
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64.
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論文
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Minimum requirements for substrates of mammalian tRNA 3' processing endoribonuclease Biochemistry 38,pp.12089-12096 (共著) 1999/09
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65.
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論文
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Long 5' leaders inhibit removal of a 3' trailer from a precursor tRNA by mammalian tRNA 3' processing endoribonuclease. Nucleic Acids Research 27,pp.2770-2776 (共著) 1999/07
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66.
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論文
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Selection of cleavage site by mammalian tRNA 3' processing endoribonuclease Journal of Molecular Biology 287,pp.727-740 (共著) 1999/04
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67.
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論文
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The mature 3'-CCA end is an anti-determinant for eukaryotic 3'-tRNase RNA 5,pp.245-256 (共著) 1999/02
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68.
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論文
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RNA heptamers that direct RNA cleavage by mammalian tRNA 3' processing endoribonuclease. Nucleic Acids Research 26,pp.2565-2571 (共著) 1998/06
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69.
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論文
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Distribution of both lengths and 5' terminal nucleotides of mammalian pre-tRNA 3' trailers reflects properties of 3' processing endoribonuclease Nucleic Acids Research 25,pp.1148-1154 (単著) 1997/03
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70.
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論文
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Specific cleavage of target RNAs from HIV-1 with 5' half tRNA by mammalian tRNA 3' processing endoribonuclease RNA 2,pp.2523-2524 (単著) 1996/03
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71.
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論文
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Conversion of mammalian tRNA 3' processing endoribonuclease to four-base-recognizing RNA cutters Nucleic Acids Res 23,pp.3642-3647 (単著) 1995/09
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72.
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論文
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3' truncated tRNAArg is essential for in vitro specific cleavage of partially synthesized mouse 18S rRNA Nucleic Acids Research 21,pp.4696-4702 (単著) 1993/10
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73.
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論文
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Characterization of the spermidine-dependent, sequence-specific endoribonuclease that requires transfer RNA for its activity Nucleic Acids Research 20,pp.3737-3742 (単著) 1992/07
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74.
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論文
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tRNAを含む塩基配列特異的エンドリボヌクレアーゼ―RNase 65 Cell Science 8,23-26頁 (単著) 1992
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75.
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論文
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tRNAを含む塩基配列特異的エンドリボヌクレアーゼ(RNase 65)―RNAワールドの分子化石?― Viva Origino 20,215-224頁 (単著) 1992
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76.
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論文
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生命の起源とRNA研究の新たな展開 SUT Bulletin (6月),20-25頁 (単著) 1992
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77.
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論文
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Transfer RNA lacking 3' terminus is required for spermidine-dependent Ribonuclease 65 activity in mouse FM3A cell extracts Biochem. Biophys. Res. Commun. 178,pp.1247-1252 (共著) 1991/08
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78.
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論文
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A novel spermidine-dependent endoribonuclease activity caused by RNA-protein complex in mouse FM3A cell extracts Biochem. Biophys. Res. Commun. 176,pp.1163-1169 (共著) 1991/05
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79.
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論文
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RNA編集 代謝 28,78頁 (共著) 1991
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80.
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論文
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A model for regulation of mammalian ribosomal DNA transcription: Coordination of initiation and termination Biochemical Journal 256,pp.329-333 (共著) 1988/12
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81.
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論文
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In vitro sequence-specific cleavage in transcribed spacer of mouse precursor ribosomal RNA Journal of Biochemistry 103,pp.992-997 (共著) 1988/06
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5件表示
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全件表示(81件)
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