ニシヤマ　ソウイチロウ   Soichiro Nishiyama   西山　宗一郎    所属   新潟薬科大学  応用生命科学部 応用生命科学科    職種   准教授
言語種別	英語
発行・発表の年月	2013/08
形態種別	論文
査読	査読あり
標題	Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis.
執筆形態	共著
掲載誌名	Molecular oral microbiology
掲載区分	国外
巻・号・頁	28(4),pp.239-49
著者・共著者	◎Hajishengallis G, McIntosh M L, Nishiyama S, Yoshimura F
概要	In monocytes and macrophages, the interaction of Porphyromonas gingivalis with TLR2 leads to the activation of a MyD88-dependent antimicrobial pathway and a PI3K-dependent pro-adhesive pathway, which activates the β2 -integrin CR3. By means of its fimbriae, P. gingivalis binds CXCR4 and induces crosstalk with TLR2 that inhibits the MyD88-dependent antimicrobial pathway. In this paper, we showed that the binding of P. gingivalis fimbriae to CXCR4 induces CR3 activation via PI3K. An isogenic strain of P. gingivalis expressing mutant fimbriae that do not interact with CXCR4 failed to efficiently activate CR3, leading to enhanced susceptibility to killing in vivo compared with the wild-type organism. Taken together, these results indicate that the interaction of P. gingivalis with CXCR4 leads to inhibition of antimicrobial responses and enhancement of pro-adhesive responses.
DOI	10.1111/omi.12021
ISSN	2041-1014
PMID	23331495