アオキ　サダオ   Sadao Aoki   青木　定夫    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2016/06
形態種別	論文
査読	査読あり
標題	Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version.
執筆形態	共著
掲載誌名	International journal of hematology
掲載区分	国外
巻・号・頁	103(6),pp.686-92
著者・共著者	Masaki Yasufumi, Kawabata Hiroshi, Takai Kazue, Kojima Masaru, Tsukamoto Norifumi, Ishigaki Yasuhito, Kurose Nozomu, Ide Makoto, Murakami Jun, Nara Kenji, Yamamoto Hiroshi, Ozawa Yoko, Takahashi Hidekazu, Miura Katsuhiro, Miyauchi Tsutomu, Yoshida Shinichirou, Momoi Akihito, Awano Nobuyasu, Ikushima Soichiro, Ohta Yasunori, Furuta Natsue, Fujimoto Shino, Kawanami Haruka, Sakai Tomoyuki, Kawanami Takafumi, Fujita Yoshimasa, Fukushima Toshihiro, Nakamura Shigeo, Kinoshita Tomohiro, Aoki Sadao
概要	TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several clinical and pathological characteristics of TAFRO syndrome resemble those of multicentric Castleman disease (MCD), other specific features can differentiate between them. Some TAFRO syndrome patients have been successfully treated with glucocorticoids and/or immunosuppressants, including cyclosporin A, tocilizumab and rituximab, whereas others are refractory to treatment, and eventually succumb to the disease. Early and reliable diagnoses and early treatments with appropriate agents are essential to enhancing patient survival.
DOI	10.1007/s12185-016-1979-1
ISSN	1865-3774
PMID	27084250