ニシヤマ　ソウイチロウ   Soichiro Nishiyama   西山　宗一郎    所属   新潟薬科大学  応用生命科学部 応用生命科学科    職種   准教授
言語種別	英語
発行・発表の年月	2006/10
形態種別	論文
査読	査読あり
標題	Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus.
執筆形態	共著
掲載誌名	Cellular microbiology
掲載区分	国外
巻・号・頁	8(10),pp.1557-70
著者・共著者	◎Hajishengallis George, Tapping Richard I, Harokopakis Evlambia, Nishiyama So-ichiro, Ratti Pukar, Schifferle Robert E, Lyle Elizabeth A, Triantafilou Martha, Triantafilou Kathy, Yoshimura Fuminobu
概要	The LPS and fimbriae of Porphyromonas gingivalis play important roles in periodontal inflammation and pathogenesis. We investigated fimbriae and LPS from several P. gingivalis strains in terms of relative dependence on TLR signalling partners and determined induced assembly of receptor complexes in lipid rafts. Fimbriae could utilize TLR1 or TLR6 for cooperative TLR2-dependent activation of transfected cell lines, in contrast to LPS and a mutant version of fimbriae which displayed preference for TLR1. In summary, TLR2 activation by P. gingivalis LPS or fimbriae involves differential dependence on accessory signalling or ligand-binding receptors, which may differentially influence innate immune responses.
DOI	10.1111/j.1462-5822.2006.00730.x
ISSN	1462-5814
PMID	16984411