マツモト　ヒトシ   Hitoshi Matsumoto   松本　均    所属   新潟薬科大学  応用生命科学部 生命産業ビジネス学科    新潟薬科大学  応用生命科学部 応用生命科学科    職種   教授
言語種別	英語
発行・発表の年月	2019/09
形態種別	総説・解説
査読	査読あり
標題	Therapeutic Effects of Anthocyanins for Vision　and Eye Health
執筆形態	共著
掲載誌名	molecules
掲載区分	国外
出版社・発行元	MDPI
巻・号・頁	24,pp.3311
著者・共著者	Yuri Nomi, Keiko Iwasaki-Kurashige and Hitoshi Matsumoto
概要	Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. And AC passes through the blood-aqueous fluid barrier and bloodretinal barrier. In vitro study, AC had a relaxing effect on ciliary muscle which is important to treat both myopia and glaucoma. And AC stimulate the regeneration of rhodopsin in frog rod outer segment. Furthermore, AC could inhibit the axial length and ocular length elongation in a negative lens-induced chick myopia model. In addition, we summarized clinical studies of AC intake improved dark adaptation and transient myopic shift and the improvement on retinal blood circulation in normal tension glaucoma patients.