エンドウ　ヤスヒロ   YASUHIRO ENDO   遠藤　康弘    所属   新潟薬科大学  医療技術学部 学部付    職種   准教授
言語種別	英語
発行・発表の年月	2024/09/01
形態種別	論文 - 研究論文（学術雑誌）
標題	Bridging the Gap Between the Bench and Bedside: Clinical Applications of High-density Lipoprotein Function.
執筆形態	単著（従来区分）
掲載誌名	Journal of atherosclerosis and thrombosis
掲載区分	国内
巻・号・頁	31(9),pp.1239-1248
担当区分	筆頭著者,責任著者
著者・共著者	Yasuhiro Endo,Kei Sasaki,Katsunori Ikewaki
概要	Decades of research have reshaped our understanding of high-density lipoprotein (HDL) , shifting our focus from cholesterol (C) levels to multifaceted functionalities. Epidemiological studies initially suggested an association between HDL-C levels and cardiovascular disease (CVD) risk; however, such a simple association has not been indicated by recent studies. Notably, genome-wide studies have highlighted discrepancies between HDL-C levels and CVD outcomes, urging a deeper exploration of the role of HDL. The key to this shift lies in elucidating the role of HDL in reverse cholesterol transport (RCT), which is a fundamental anti-atherosclerotic mechanism. Understanding RCT has led to the identification of therapeutic targets and novel interventions for atherosclerosis. However, clinical trials have underscored the limitations of HDL-C as a therapeutic target, prompting the re-evaluation of the role of HDL in disease prevention. Further investigations have revealed the involvement of HDL composition in various diseases other than CVD, including chronic kidney disease, Alzheimer's disease, and autoimmune diseases. The anti-inflammatory, antioxidative, and anti-infectious properties of HDL have emerged as crucial aspects of its protective function, opening new avenues for novel biomarkers and therapeutic targets. Omics technologies have provided insights into the diverse composition of HDL, revealing disease-specific alterations in the HDL proteome and lipidome. In addition, combining cell-based and cell-free assays has facilitated the evaluation of the HDL functionality across diverse populations, offering the potential for personalized medicine. Overall, a comprehensive understanding of HDL multifunctionality leads to promising prospects for future clinical applications and therapeutic developments, extending beyond cardiovascular health.
DOI	10.5551/jat.RV22020
PMID	38925924