オオタケサトウ　マルセロ   Marcello Otake Sato    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2026
形態種別	論文（従来区分）
査読	査読あり
標題	Comparative assessment of immunochromatographic test kits using low-molecular-weight antigens from cyst fluids of two different genotypes of Taenia solium for serodiagnosis of human cysticercosis.
執筆形態	共著（従来区分）
掲載誌名	Parasite (Paris, France)
掲載区分	国外
出版社・発行元	EDP Sciences
巻・号・頁	33,pp.3
国際共著	国際共著
著者・共著者	Lakkhana Sadaow, Penchom Janwan, Patcharaporn Boonroumkaew, Rutchanee Rodpai, Oranuch Sanpool, Tongjit Thanchomnang, Marcello Otake Sato, Pewpan M Intapan, Hiroshi Yamasaki, Yasuhito Sako, Toni Wandra, Kadek Swastika, Wanchai Maleewong
概要	Human cysticercosis is a serious zoonosis caused by infection with larvae (cysticerci) of the pork tapeworm, Taenia solium. Infection can involve the nervous system, causing chronic headache and intracranial hypertension, focal neurological deficits, epileptic seizures, and paralysis. The disease is found in developing countries, where porcine cysticercosis is prevalent and undercooked pork is habitually consumed. This study aimed to develop immunochromatography-based test (ICT) kits, using low-molecular-weight antigens purified from cyst fluids of Latin American and Asian genotypes of T. solium. To evaluate the kits, we used 164 serum samples, including 24 from proven/confirmed cysticercosis cases, 110 from cases with other parasitoses, and 30 from healthy individuals. Diagnostic performances were calculated. The sensitivity, specificity, and accuracy were 83.3% (95% CI [62.6-95.3]), 93.6% (95% CI [88.1-97.0]), and 92.1% (95% CI [86.8-95.7]), respectively for the American genotype-based ICT kit, while for the Asian genotype-based ICT kit, they were 87.5% (95% CI [67.6-97.3]), 98.6% (95% CI [94.9-99.8]), and 97.0% (95% CI [93.0-99.0]), respectively. The sensitivity and specificity did not significantly differ between the two ICT kits (exact McNemar's test; p > 0.05), with a concordance of 93.9%, represented by a Cohen's kappa of 0.77 (p < 0.001), indicating substantial agreement. These results indicate that affinity-purified antigens from different geographical isolates can be used for the diagnosis of human cysticercosis. The diagnostic specificities were better than for a previously reported ICT kit that used crude antigen.
DOI	10.1051/parasite/2026003
ISSN	1776-1042
PMID	41575056