エンドウ　ヤスヒロ   YASUHIRO ENDO   遠藤　康弘    所属   新潟薬科大学  医療技術学部 学部付    職種   准教授
言語種別	日本語
発行・発表の年月	2025
形態種別	論文 - 研究論文（学術雑誌）
標題	[A case of hyponatremia induced by the thiazide-like diuretic indapamide in an elderly woman].
執筆形態	単著（従来区分）
掲載誌名	Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
掲載区分	国内
巻・号・頁	62(1),88-92頁
著者・共著者	Nobuya Nakaguki,Kei Sasaki,Yasuhiro Endo,Katsunori Ikewaki
概要	A 72-year-old woman with a history of hypertension who had already been taking calcium channel blockers and angiotensin II receptor blockers was prescribed additional indapamide (1 mg/day) due to inadequate blood pressure control. Two weeks later, she experienced loss of appetite and fatigue. Seeking medical attention, she was diagnosed with significant hyponatremia with a serum sodium level of 110 mEq/L at a local clinic, leading to her referral and subsequent admission to our department. Although her consciousness remained clear, laboratory findings revealed a serum sodium level of 116 mEq/L, blood urea nitrogen of 7 mg/dL, blood glucose of 96 mg/dL, and plasma osmolarity of 239.8 mOsm/kg·H2O, consistent with hypotonic hyponatremia induced by indapamide. Indapamide was discontinued and normal saline was administered. By the 6th day of hospitalization, her serum sodium level had improved to 130 mEq/L, and her symptoms had resolved.Thiazide-like diuretics can induce hyponatremia as a side effect with diverse symptoms and variable onset. However, in this case, hyponatremia was promptly detected shortly after the initiation of indapamide therapy, and no gastrointestinal symptoms other than anorexia were observed. When initiating thiazide-like diuretics, it is essential to be vigilant for hyponatremia and to provide appropriate medication guidance to patients in addition to monitoring their serum sodium levels.
DOI	10.3143/geriatrics.62.88
PMID	40159210