|
トウ ヒデヒロ
藤 英博 所属 新潟薬科大学 応用生命科学部 学部付 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2024/10 |
| 形態種別 | 論文 |
| 標題 | Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity |
| 執筆形態 | 共著 |
| 掲載誌名 | bioRxiv (preprint) |
| 掲載区分 | 国外 |
| 出版社・発行元 | Cold Spring Harbor Laboratory |
| 巻・号・頁 | pp.2024.10.11.617779 |
| 著者・共著者 | Kenichiro Hirotani,Kazufumi Kunimura,Rae Maeda,Yuki Sugiura,Keisuke Nakata,Masatomo Takahashi,Yoshihiro Izumi,Sayaka Akiyoshi,Keisuke Matsubara,Kenji Morino,Takeshi Iwasaki,Kaori Tanaka,Fadlina Aulia,Kanjiro Miyata,Takanatsu Hosokawa,Takeshi Mori,Yasuyuki Ohkawa,Takeshi Bamba,Hidehiro Toh,Hiroyuki Sasaki,Yoshinao Oda,Takehito Uruno,Kiyoko Kato,Yoshinori Fukui |
| 概要 | Abstract
Although placental mammals are at high risk of maternal–fetal immune conflict, it is unclear how the semi-allogeneic fetus avoids rejection. Cholesterol sulfate (CS) is a bioactive metabolite that inhibits leukocyte migration and activation. This study investigated the roles and cells associated with CS in pregnant mice and humans. CS was sequentially produced by maternal-derived endometrial cells and fetal-derived placental trophoblasts before and after placentation. When mated with allogeneic males, CS-deficient mice showed increased fetal resorption rates under induced placental inflammation. This phenotype disappeared when the activity of the CS-producing enzyme was restored in the placenta. Placental CS levels were reduced in patients with “villitis of unknown etiology.” Thus, we uncovered the spatiotemporal control of CS production and its relevance to local immunosuppression during pregnancy. |
| DOI | 10.1101/2024.10.11.617779 |
| PermalinkURL | https://syndication.highwire.org/content/doi/10.1101/2024.10.11.617779 |