オオタケサトウ　マルセロ   Marcello Otake Sato    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2022/08
形態種別	論文
査読	査読あり
標題	Circulating microRNAs as Biomarkers of Hepatic Fibrosis in Schistosomiasis Japonica Patients in the Philippines.
執筆形態	共著
掲載誌名	Diagnostics (Basel, Switzerland)
掲載区分	国外
巻・号・頁	12(8)
著者・共著者	◎Ian Kim B Tabios, Marcello Otake Sato, Ourlad Alzeus Gaddi Tantengco, Raffy Jay C Fornillos, Masashi Kirinoki, Megumi Sato, Raniv D Rojo, Ian Kendrich C Fontanilla, Yuichi Chigusa, Paul Mark B Medina, Mihoko Kikuchi, Lydia R Leonardo
概要	The serum levels of the antifibrotic miR-146a (p < 0.0001), miR-150 (p = 0.0058), and let-7a (p < 0.0001) were significantly lower in patients with hepatic fibrosis while the profibrotic miR-93 (p = 0.0024) was elevated. miR-146a-5p (AUC = 0.90, 95% CI [0.84, 0.96], p < 0.0001) has the most promising potential to differentiate patients with (n = 78) versus without (n = 58) hepatic fibrosis. The baseline level of serum miR-146-5p was significantly different in patients with progressive fibrosis (n = 17) compared to those who never developed fibrosis (n = 30, p < 0.01) or those who had fibrosis reversal (n = 20, p < 0.01) after 24 months. These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients.
DOI	10.3390/diagnostics12081902
ISSN	2075-4418
PMID	36010252