オオタケサトウ　マルセロ   Marcello Otake Sato    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	日本語
発行・発表の年月	2022/08
形態種別	論文
査読	査読あり
標題	Circulating microRNAs as Biomarkers of Hepatic Fibrosis in Schistosomiasis Japonica Patients in the Philippines.
執筆形態	共著
掲載誌名	Diagnostics (Basel, Switzerland)
掲載区分	国外
巻・号・頁	12(8)
著者・共著者	Ian Kim B Tabios, Marcello Otake Sato, Ourlad Alzeus Gaddi Tantengco, Raffy Jay C Fornillos, Masashi Kirinoki, Megumi Sato, Raniv D Rojo, Ian Kendrich C Fontanilla, Yuichi Chigusa, Paul Mark B Medina, Mihoko Kikuchi, Lydia R Leonardo
概要	The serum levels of the antifibrotic miR-146a (p < 0.0001), miR-150 (p = 0.0058), and let-7a (p < 0.0001) were significantly lower in patients with hepatic fibrosis while the profibrotic miR-93 (p = 0.0024) was elevated. miR-146a-5p (AUC = 0.90, 95% CI [0.84, 0.96], p < 0.0001) has the most promising potential to differentiate patients with (n = 78) versus without (n = 58) hepatic fibrosis. The baseline level of serum miR-146-5p was significantly different in patients with progressive fibrosis (n = 17) compared to those who never developed fibrosis (n = 30, p < 0.01) or those who had fibrosis reversal (n = 20, p < 0.01) after 24 months. These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients.
DOI	10.3390/diagnostics12081902
ISSN	2075-4418
PMID	36010252