ワタナベ　ケイスケ   渡辺　啓介    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2006/05
形態種別	論文
査読	査読あり
標題	Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells
執筆形態	共著
掲載誌名	DEVELOPMENTAL BIOLOGY
掲載区分	国外
出版社・発行元	ACADEMIC PRESS INC ELSEVIER SCIENCE
巻・号・頁	293(2),pp.358-369
著者・共著者	N Masahira,H Takebayashi,K Ono,K Watanabe,L Ding,M Furusho,Y Ogawa,Y Nabeshima,A Alvarez-Buylla,K Shimizu,K Ikenaka
概要	Motoneurons and oligodendrocytes in the embryonic spinal cord are produced from a restricted domain of the ventral ventricular zone, termed the pMN domain. The pMN domain is the site of expression of two basic helix-loop-helix transcription factors, Olig1 and Olig2, which are essential for motoneuron and oligodendrocyte development. Previous lineage-tracing experiments using Olig1-Cre and Olig2-GFP mice suggested that motoneurons and oligodendrocytes, but not astrocytes, are produced from the pMN domain. However, important questions remain, including the fate of neuroepithelial cells in the pMN domain, and specifically whether motoneurons and oligodendrocytes are the only types of cells produced in the pMN domain. We performed lineage-tracing experiments using a tamoxifen-inducible Cre-recombinase inserted into the Olig2 locus. We demonstrated that motoneurons and oligodendrocyte progenitors are derived from the Olig2(+) progenitors in the pMN domain, and also found that a subset of astrocytes at the ventral surface of the spinal cord and ependymal cells at the ventricular surface are also produced from the pMN domain. These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain. (c) 2006 Elsevier Inc. All rights reserved.
DOI	10.1016/j.ydbio.2006.02.029
ISSN	0012-1606
NAID	80019129851
PMID	16581057