ノズミ　モトヒロ   野住　素広    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2010/10/21
形態種別	論文 - 研究論文（学術雑誌）
査読	査読あり
標題	A stochastic model of neuronal growth cone guidance regulated by multiple sensors.
執筆形態	その他 - 指定なし
掲載誌名	Journal of theoretical biology
掲載区分	国外
巻・号・頁	266(4),pp.712-22
著者・共著者	Taichiro Kobayashi,Kenshi Terajima,Motohiro Nozumi,Michihiro Igarashi,Kouhei Akazawa
概要	Neuronal growth cones migrate directionally under the control of axon guidance molecules, thereby forming synapses in the developing brain. The signal transduction system by which a growth cone detects surrounding guidance molecules, analyzes the detected signals, and then determines the overall behavior remains undetermined. In this study, we describe a novel stochastic model of this behavior that utilizes multiple sensors on filopodia to respond to guidance molecules. Overall growth cone behavior is determined by using only the concentration gradients of guidance molecules in the immediate vicinity of each sensor. The detected signal at each sensor, which is treated as a vector quantity, is sent to the growth cone center and then integrated to determine axonal growth in the next step by means of a simple vector operation. We compared the results of computer simulations of axonal growth with observations of actual axonal growth from co-culture experiments using olfactory bulb and septum. The probabilistic distributions of axonal growth generated by the computer simulation were consistent with those obtained from the culture experiments, indicating that our model accurately simulates growth cone behavior. We believe that this model will be useful for elucidating the as yet unknown mechanisms responsible for axonal growth in vivo.
DOI	10.1016/j.jtbi.2010.07.036
PMID	20688081