ワタナベ　ケイスケ   渡辺　啓介    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2009/03
形態種別	論文
査読	査読あり
標題	Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice
執筆形態	共著
掲載誌名	NEUROSCIENCE RESEARCH
掲載区分	国外
出版社・発行元	ELSEVIER IRELAND LTD
巻・号・頁	63(3),pp.213-223
著者・共著者	Chiyoko Tanahira,Shigeyoshi Higo,Keisuke Watanabe,Ryohei Tomioka,Satoe Ebihara,Takeshi Kaneko,Nobuaki Tamamaki
概要	Neurons expressing the calcium-binding protein parvalbumin (PV) constitute an abundant subpopulation of GABAergic neurons in the cerebral cortex. However, PV is not unique to the GABAergic neurons of the forebrain, but is also expressed in a small number of pyramidal neurons and in a large number of thalamic neurons. In order to summarize the PV neurons in the forebrain, we employed the PV-Cre transgenic mice in the present study. In the progeny of crossbreed between PV-Cre mice and GFP-Cre reporter mice, we found that the GFP-positive neurons include many excitatory neurons in the neocortex and the thalamus as well as GABAergic neurons in the cerebral cortex and basal ganglia. All the reported PV-positive GABAergic neurons in the cerebral cortex and the basal ganglia seemed to be included in the GFP-positive cells. We found GFP-positive layer V pyramidal neurons inhabit a broader neocortical area than was previously reported. They were located in the primary somatosensory, motor, and visual areas. The somatosensory area of the neocortex contained the greatest number of PV-positive pyramidal neurons. A large number of thalamic relay neurons and virtually all the reticular thalamic neurons appeared as GFP-positive. Thalamic relay nucleus and a neocortical area for the same modality corresponded and seemed to contain a characteristic amount of PV-positive excitatory neurons. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
DOI	10.1016/j.neures.2008.12.007
ISSN	0168-0102
NAID	80020143629
PMID	19167436