エンドウ　ヤスヒロ   YASUHIRO ENDO   遠藤　康弘    所属   新潟薬科大学  医療技術学部 学部付    職種   准教授
言語種別	英語
発行・発表の年月	2023/01/04
形態種別	論文 - 研究論文（学術雑誌）
標題	HDL Functions-Current Status and Future Perspectives.
執筆形態	単著（従来区分）
掲載誌名	Biomolecules
掲載区分	国外
巻・号・頁	13(1)
担当区分	筆頭著者
著者・共著者	Yasuhiro Endo,Masanori Fujita,Katsunori Ikewaki
概要	Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically increased CVD mortality in patients with extremely high HDL-C levels. Furthermore, HDL-C raising therapy using nicotinic acids or CETP inhibitors mostly failed to reduce CVD events. Based on this background, HDL functions rather than HDL-C could be a novel biomarker; research on the clinical utility of HDL functionality is ongoing. In this review, we summarize the current status of HDL functions and their future perspectives from the findings of basic research and clinical trials.
DOI	10.3390/biom13010105
PMID	36671490