ニシヤマ　ソウイチロウ   Soichiro Nishiyama   西山　宗一郎    所属   新潟薬科大学  応用生命科学部 応用生命科学科    職種   准教授
言語種別	英語
発行・発表の年月	2009/08
形態種別	論文
査読	査読あり
標題	Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.
執筆形態	共著
掲載誌名	Infection and immunity
掲載区分	国外
巻・号・頁	77(8),pp.3294-301
著者・共著者	◎Pierce Deanne L, Nishiyama So-ichiro, Liang Shuang, Wang Min, Triantafilou Martha, Triantafilou Kathy, Yoshimura Fuminobu, Demuth Donald R, Hajishengallis George
概要	The fimbriae of Porphyromonas gingivalis mediate critical roles in host colonization and evasion of innate defenses and comprise polymerized fimbrilin (FimA) associated with accessory proteins (FimCDE) of unknown function. We now show that P. gingivalis fimbriae lacking FimCDE fail to interact with the CXCR4. Purified FimC and FimD (but not FimE) were shown to interact with CXCR4. In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins. These data and the fact that FimE is required for the association of FimCDE with P. gingivalis fimbriae suggest that FimE may recruit FimC and FimD into a functional complex. Consistent with this notion, FimE was shown to bind both FimC and FimD. In summary, the FimCDE components cooperate and impart critical adhesive and virulence properties to P. gingivalis fimbriae.
DOI	10.1128/IAI.00262-09
ISSN	1098-5522
PMID	19506009