ノズミ　モトヒロ   野住　素広    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2018/10
形態種別	論文 - 研究論文（学術雑誌）
査読	査読あり
標題	Vesicular movements in the growth cone.
執筆形態	その他 - 指定なし
掲載誌名	Neurochemistry international
掲載区分	国外
巻・号・頁	119,pp.71-76
著者・共著者	Motohiro Nozumi,Michihiro Igarashi
概要	Growth cones, which are the highly motile tips of extending neuronal processes in developing neurons, have many vesicles. These vesicles are likely essential for the membrane expansion that is required for nerve growth, and probably coordinate with rearrangement of the cytoskeletons. Such mechanisms are poorly understood from molecular and cell biological aspects. Recently, we used superresolution microscopic approaches and described new mechanisms that are involved in the interaction between the vesicles and F-actin in the leading edge of the peripheral domain. Vesicles mainly accumulate in the central domain of growth cones. However, the dynamics of vesicles in each domain, for example, clathrin dependency, are totally distinct from each other. Here, we discuss the diversity of the dynamics of vesicular and related proteins that play different roles in nerve growth.
DOI	10.1016/j.neuint.2017.09.011
PMID	28962923