ノズミ　モトヒロ   野住　素広    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2018/10/31
形態種別	論文 - 研究論文（学術雑誌）
査読	査読あり
標題	New observations in neuroscience using superresolution microscopy.
執筆形態	その他 - 指定なし
掲載誌名	The Journal of neuroscience : the official journal of the Society for Neuroscience
掲載区分	国外
巻・号・頁	38(44),pp.9459-9467
著者・共著者	Michihiro Igarashi,Motohiro Nozumi,Ling-Gang Wu,Francesca Cella Zanacchi,István Katona,László Barna,Pingyong Xu,Mingshu Zhang,Fudong Xue,Edward Boyden
概要	Superresolution microscopy (SM) techniques are among the revolutionary methods for molecular and cellular observations in the 21st century. SM techniques overcome optical limitations, and several new observations using SM lead us to expect these techniques to have a large impact on neuroscience in the near future. Several types of SM have been developed, including structured illumination microscopy (SIM), stimulated emission depletion microscopy (STED), and photoactivated localization microscopy (PALM)/stochastic optical reconstruction microscopy (STORM), each with special features. In this Minisymposium, experts in these different types of SM discuss the new structural and functional information about specific important molecules in neuroscience that has been gained with SM. Using these techniques, we have revealed novel mechanisms of endocytosis in nerve growth, fusion pore dynamics, and described quantitative new properties of excitatory and inhibitory synapses. Additional powerful techniques, including single molecule-guided Bayesian localization SM (SIMBA) and expansion microscopy (ExM), alone or combined with super-resolution observation, are also introduced in this session.
DOI	10.1523/JNEUROSCI.1678-18.2018
PMID	30381437