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エンドウ ヤスヒロ
YASUHIRO ENDO
遠藤 康弘 所属 新潟薬科大学 医療技術学部 学部付 職種 准教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2023/08/01 |
| 形態種別 | 論文 - 研究論文（学術雑誌） |
| 標題 | Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin-Cholesterol Acyltransferase Autoantibody. |
| 執筆形態 | 単著（従来区分） |
| 掲載誌名 | Journal of atherosclerosis and thrombosis |
| 掲載区分 | 国内 |
| 巻・号・頁 | 30(8),pp.1070-1082 |
| 著者・共著者 | Tomohiro Komatsu,Yuka Katsurada,Kazuya Miyashita,Satomi Abe,Takafumi Nishida,Yasuhiro Endo,Manami Teramoto,Kei Sasaki,Junko Arakawa,Makoto Sasaki,Natsuko Suzuki,Koji Kuwata,Toshihiko Imakiire,Takayuki Miyake,Masami Sakurada,Susumu Matsukuma,Tsutomu Hirano,Yoshinari Uehara,Katsunori Ikewaki |
| 概要 | Lecithin-cholesterol acyltransferase (LCAT) plays a significant role in the progression from premature to mature high-density lipoprotein (HDL) in circulation. Consequently, primary or secondary LCAT deletion or reduction naturally results in low serum HDL cholesterol levels. Recently, rare cases of acquired HDL deficiency with LCAT autoantibodies have been reported, mainly from Japan, where LCAT autoantibodies of immunoglobulin G (IgG) caused the HDL deficiency. Here to our knowledge, we report for the first time two cases of acquired HDL deficiency caused by IgG4 linked LCAT autoantibodies with or without a high serum IgG4 level. Furthermore, these cases can extend to a new concept of "IgG4 autoimmune disease" from the viewpoint of verifying the serum autoantibody and/or renal histopathology. |
| DOI | 10.5551/jat.63616 |
| PMID | 36384970 |