マエダ　タケヒコ   MAEDA TAKEHIKO   前田　武彦    所属   新潟薬科大学  薬学部 薬学科    職種   教授
言語種別	英語
発行・発表の年月	2025/11
形態種別	論文（従来区分）
査読	査読あり
標題	Autocrine Semaphorin 6B Signaling Is Essential for Tumorigenesis in Lung Cancer
執筆形態	共著（従来区分）
掲載誌名	BPB Reports
掲載区分	国外
出版社・発行元	公益社団法人 日本薬学会
巻・号・頁	8(1),pp.18-22
著者・共著者	Yamada Daisuke, Hasegawa Takuya, Kawahara Kohichi, Maeda Takehiko
概要	<p>Semaphorin family belongs to secreted or membrane anchored proteins. Recent studies have demonstrated the involvement of semaphorins and their receptors in cancer biology, but it remains unclear how each semaphorin molecule regulates tumorigenesis. Previously we reported that Semaphorin 3A (Sema3A) and its receptor Plexin A1 (PlxnA1) regulate the malignant phenotypes of mouse-derived lewis lung cancer (LLC) cells constitutively expressing GFP (LLC-GFP). Here we show that Semaphorin 6B (Sema6b) serves as one of the oncogenic semaphorin molecules in lung cancer using LLC-GFP. Sema3a or Plxna1 knockdown downregulated Sema6b, and their suppressive effect on proliferation was significantly recovered by recombinant SEMA6B (rSEMA6B) treatment. Sema6b knockdown suppressed the proliferation and tumorigenicity of LLC-GFP. Interestingly, the self-renewal capacity of LLC-GFP derived cancer stem-like cells (LLC-GFPstem) was completely lost by Sema6b knockdown. These results demonstrate that Sema6B would be the novel therapeutic target of lung cancer.</p>
DOI	10.1248/bpbreports.8.1_18
NAID	1390584796489826816