マエダ　タケヒコ   MAEDA TAKEHIKO   前田　武彦    所属   新潟薬科大学  薬学部 薬学科    職種   教授
言語種別	英語
発行・発表の年月	2025/11
形態種別	論文（従来区分）
査読	査読あり
標題	Plexin A1 Is Essential for Tumorigenic Capacity of Mouse Lewis Lung Carcinoma Cell-Derived Cancer Stem Cells
執筆形態	共著（従来区分）
掲載誌名	BPB Reports
掲載区分	国外
出版社・発行元	公益社団法人 日本薬学会
巻・号・頁	8(6),pp.216-220
著者・共著者	Yamada Daisuke, Hasegawa Takuya, Maeda Takehiko
概要	<p>Plexin (Plxn) family molecules are the receptor for semaphorins and their involvement in tumor malignancy is also demonstrated. However, the regulatory roles of Plxns in cancer-stemness have not been completely understood. Previously we found that Sema3a and its receptor PlxnA1 confer the high proliferative capacity and the resistance against epidermal growth factor receptor (EGFR) inhibitors to mouse-derived lewis lung cancer (LLC) cells constitutively expressing green fluorescent protein (GFP) (LLC-GFP). Here we show that PlxnA1 is essential for maintaining cancer stem-like property of LLC-GFP-derived cancer stem cells (LLC-GFPstem). Plxna1 knockdown downregulated stem cell markers, Sox2 and Cd44, in LLC-GFPstem cells. Importantly, the sphere-forming and tumorigenic capacity of LLC-GFPstem cells was lost by Plxna1 knockdown. These results demonstrate that PlxnA1 is essential for LLC-GFPstem cells to maintain their cancer stem-like properties.</p>
DOI	10.1248/bpbreports.8.6_216
NAID	1390025098830585344