ノズミ　モトヒロ   野住　素広    所属   新潟薬科大学  医療技術学部 臨床検査学科    職種   教授
言語種別	英語
発行・発表の年月	2020
形態種別	論文 - 研究論文（学術雑誌）
査読	査読あり
標題	Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation.
執筆形態	その他 - 指定なし
掲載誌名	Frontiers in molecular neuroscience
掲載区分	国外
巻・号・頁	13,pp.150-150
著者・共著者	Michihiro Igarashi,Atsuko Honda,Asami Kawasaki,Motohiro Nozumi
概要	Neuronal polarization and growth are developmental processes that occur during neuronal cell differentiation. The molecular signaling mechanisms involved in these events in in vivo mammalian brain remain unclear. Also, cellular events of the neuronal polarization process within a given neuron are thought to be constituted of many independent intracellular signal transduction pathways (the "tug-of-war" model). However, in vivo results suggest that such pathways should be cooperative with one another among a given group of neurons in a region of the brain. Lipid rafts, specific membrane domains with low fluidity, are candidates for the hotspots of such intracellular signaling. Among the signals reported to be involved in polarization, a number are thought to be present or translocated to the lipid rafts in response to extracellular signals. As part of our analysis, we discuss how such novel molecular mechanisms are combined for effective regulation of neuronal polarization and growth, focusing on the significance of the lipid rafts, including results based on recently introduced methods.
DOI	10.3389/fnmol.2020.00150
PMID	32922262