マエダ　タケヒコ   MAEDA TAKEHIKO   前田　武彦    所属   新潟薬科大学  薬学部 薬学科    職種   教授
発行・発表の年月	2024/11
形態種別	論文（従来区分）
査読	査読あり
標題	Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia
執筆形態	共著（従来区分）
掲載誌名	Current Issues in Molecular Biology
掲載区分	国外
出版社・発行元	MDPI AG
巻・号・頁	46(12),13364-13382頁
著者・共著者	Takuya Hasegawa, Kohichi Kawahara, Koji Sato, Yoshihisa Asano, Takehiko Maeda
概要	<jats:p>Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remain elusive. Therefore, there is a greater need for well-characterized animal models to identify novel therapeutic targets. Certain manifestations of cachexia, such as pain and depression, have been extensively studied using animal models of cancer-induced bone pain (CIBP). In contrast, other aspects of cachexia have received less attention in these models. To address this issue, we established the CIBP model by injecting Lewis lung carcinoma into the intramedullary cavity of the femur, observed cachexia-related symptoms, and demonstrated the utility of this model as a preclinical platform to study cancer cachexia. This model accurately recapitulates key features of cancer cachexia, including weight loss, muscle atrophy, adipose tissue depletion, CIBP, and anxiety. These findings suggest that psychological factors, in addition to physiological and metabolic factors, play significant roles in cancer cachexia development. Our model offers a valuable resource for investigating the underlying mechanisms of cancer cachexia and for developing innovative therapeutic strategies that target physical and psychological components.</jats:p>
DOI	10.3390/cimb46120797
NAID	1360025430195559168